Fire

i know exactly where you got this from. this guy needs to work for lucasarts 😎

Kendrick did say he has two tees with him perhaps he is golfing with Drake

y'all seen thi?

@Extraterrestrial
@Camille

Yeah I’m still hard

10:23am

Contra-indications
Contra-indicationsFor all opioids
Acute respiratory depression; comatose patients; head injury (opioid a***gesics interfere with pupillary responses vital for neurological assessment); raised intracranial pressure (opioid a***gesics interfere with pupillary responses vital for neurological assessment); risk of paralytic ileus

Contra-indicationsFor oxycodone hydrochloride
Acute abdomen; chronic constipation; cor pulmonale; delayed gastric emptying

Cautions
CautionsFor all opioids
Adrenocortical insufficiency (reduced dose is recommended); asthma (avoid during an acute attack); central sleep apnoea; convulsive disorders; current or history of mental health disorder; current or history of substance use disorder; debilitated patients (reduced dose is recommended); diseases of the biliary tract; elderly (reduced dose is recommended); hypotension; hypothyroidism (reduced dose is recommended); impaired respiratory function (avoid in chronic obstructive pulmonary disease); inflammatory bowel disorders; myasthenia gravis; obstructive bowel disorders; prostatic hypertrophy; shock; urethral stenosis

Cautions, further information
Dependence and addiction
Prolonged use of opioid a***gesics may lead to d*** dependence and addiction, even at therapeutic doses. There is an increased risk in individuals with current or history of substance use disorder or mental health disorders. See also Important safety information.

Central sleep apnoea
Opioids cause a dose-dependent increased risk of central sleep apnoea, consider total opioid dose reduction.

Palliative care
In the control of pain in terminal illness, the cautions listed should not necessarily be a deterrent to the use of opioid a***gesics.

Elderly
Prescription potentially inappropriate (STOPP criteria):

if prescribed a strong, oral or transdermal opioid (i.e. morphine, oxycodone, fentanyl, buprenorphine, diamorphine, methadone, tramadol, pethidine, pentazocine) as first-line therapy for mild pain (WHO a***gesic ladder not observed)
if used regularly without concomitant laxative (risk of severe constipation)
if prescribed a long-acting (modified-release) opioid without a short-acting (immediate-release) opioid for breakthrough pain (risk of persistence of severe pain)
See also Prescribing in the elderly.

CautionsFor oxycodone hydrochloride
Pancreatitis; toxic psychosis

Interactions
View interactions for oxycodone

Side-effects
Side-effectsFor all opioids
Common or very common
Arrhythmias; confusion; constipation; dizziness; drowsiness; dry mouth; euphoric mood; flushing; hallucination; headache; hyperhidrosis; miosis; nausea (more common on initiation); palpitations; respiratory depression (with high doses); skin reactions; urinary retention; vertigo; vomiting (more common on initiation); withdrawal syndrome

Uncommon
D*** dependence; dysphoria

Side-effects, further information
Respiratory depression

Respiratory depression is a major concern with opioid a***gesics and it may be treated by artificial ventilation or be reversed by naloxone.

Dependence, addiction, and withdrawal

Long term use of opioids in non-malignant pain (longer than 3 months) carries an increased risk of dependence and addiction, even at therapeutic doses. At the end of treatment the dosage should be tapered slowly to reduce the risk of withdrawal effects; tapering from a high dose may take weeks or months. See also Important safety information.

Overdose
Opioids (narcotic a***gesics) cause coma, respiratory depression, and pinpoint pupils. For details on the management of poisoning, see Opioids, under Emergency treatment of poisoning and consider the specific antidote, naloxone hydrochloride.

Side-effectsFor oxycodone hydrochloride
General side-effects:
Common or very common
Anxiety; bronchospasm; depression; diarrhoea; dyspnoea; gastrointestinal discomfort; hiccups; mood altered; tremor

Uncommon
Biliary colic; burping; chills; dehydration; dysphagia; gastrointestinal disorders; malaise; memory loss; neuromuscular dysfunction; oedema; seizure; sensation abnormal; sexual dysfunction; speech disorder; syncope; taste altered; thirst; vasodilation; visual impairment

Rare or very rare
Hypotension

Frequency not known
Aggression; amenorrhoea; cholestasis

Specific side-effects:
Common or very common
With oral use
Appetite abnormal; asthenic conditions; cognitive impairment; insomnia; movement disorders; perception altered; psychiatric disorders; urinary frequency increased

With parenteral use
Appetite decreased; asthenia; cough decreased; sleep disorders; thinking abnormal

Uncommon
With oral use
Chest pain; cough; hyperacusia; increased risk of infection; injury; lacrimation disorder; migraine; oral disorders; pain; SIADH; voice alteration

With parenteral use
Fever; hypogonadism; ureteral spasm

Rare or very rare
With oral use
Haemorrhage; lymphadenopathy; muscle spasms; photosensitivity reaction; tooth discolouration; weight changes

Frequency not known
With parenteral use
Dental caries; hyperalgesia; withdrawal syndrome neonatal

Pregnancy
PregnancyFor all opioids
Respiratory depression and withdrawal symptoms can occur in the neonate if opioid a***gesics are used during delivery; also gastric stasis and inhalation pneumonia has been reported in the mother if opioid a***gesics are used during labour.

Breast feeding
Breast feedingFor oxycodone hydrochloride
Present in milk—avoid.

Hepatic impairment
Hepatic impairmentFor oxycodone hydrochloride
Caution in mild impairment; avoid in moderate to severe impairment .

Dose adjustments
Initial dose reduction of 50% in mild impairment; adjust according to response.

Renal impairment
Renal impairmentFor oxycodone hydrochloride
Caution (risk of increased and prolonged effects).

Dose adjustments
Initial dose reduction of 50%; adjust according to response.

Treatment cessation
Treatment cessationFor all opioids
Avoid abrupt withdrawal after long-term treatment; they should be withdrawn gradually to avoid abstinence symptoms.

Directions for administration
Directions for administrationFor oxycodone hydrochloride
With intravenous use:
For intravenous infusion (Oxynorm®), manufacturer advises give continuously or intermittently in Glucose 5% or Sodium chloride 0.9%; dilute to a concentration of 1 mg/mL.

Prescribing and dispensing information
Prescribing and dispensing informationFor all opioids
The Faculty of Pain Medicine has produced resources for healthcare professionals around opioid prescribing:fpm.ac.uk/faculty-of-pain-medicine/opioids-aware

Prescribing and dispensing informationFor oxycodone hydrochloride
Modified-release preparations are available as 12-hourly or 24-hourly formulations. Preparations that should be given 12-hourly include Abtard®, Carexil®, Ixyldone®, Leveraxo®, Longtec®, Oxeltra®, OxyContin®, Oxypro®, Oxylan®, Reltebon®, and Renocontin®. Preparations that should be given 24-hourly include Onexila® XL.

Palliative care
Palliative careFor oxycodone hydrochloride
For further information on the use of oxycodone in palliative care, see medicinescomplete.com/#/content/palliative/oxycodone.

Patient and carer advice
Patient and carer adviceFor all opioids
MHRA safety leaflet: Opioid medicines and the risk of addiction
gov.uk/guidance/opioid-medicines-and-the-risk-of-addiction

Driving and skilled tasks
Drowsiness may affect performance of skilled tasks (e.g. driving); effects of alcohol enhanced. Driving at the start of therapy with opioid a***gesics, and following dose changes, should be avoided.

For information on 2015 legislation regarding driving whilst taking certain controlled d****, including opioids, see D**** and driving under Guidance on prescribing.

National funding/access decisions
National funding/access decisionsFor oxycodone hydrochloride
For full details see funding body website.

Scottish Medicines Consortium (SMC) decisionsFor oxycodone hydrochloride
SMC No. 125/04

Oxycodone injection (OxyNorm®) for the treatment of moderate to severe pain in patients with cancer (October 2004)

Funding decision:Recommended with restrictions
SMC No. 197/05

Oxycodone 5 mg, 10 mg, 20 mg, 40 mg and 80 mg prolonged release tablets (OxyContin®) for the treatment of severe non-malignant pain requiring a strong opioid (September 2005)

Funding decision:Recommended with restrictions
SMC No. 648/10

Oxycodone hydrochloride 50 mg/mL injection (OxyNorm®) for the treatment of moderate to severe pain in patients with cancer (November 2010)

Funding decision:Recommended with restrictions
Medicinal forms
There can be variation in the licensing of different medicines containing the same d***.

Forms available from special-order manufacturers include: oral solution, solution for infusion.

View all medicinal forms and pricing information

Or jump straight to:

Oral tablet
Modified-release tablet
Oral capsule
Oral solution
Solution for injection

wanna run duos king?

proof?

wait i see it now

King. This guy became so much more endearing after I saw this pic. How can you hate that guy

He really got that s*** on

gyatttt

Holy s***

@Ava_Yeezy